PROTEOMICS 2015* The Metabolic Signalling Landscape (#37)
Metabolic homeostasis is subject to major challenges particularly those imposed by starvation, diet and exercise. There has been considerable interest in dissecting the adaptations that occur in response to these kinds of perturbations and which of these are most likely to contribute to defects or constitute major points of regulation. As one approach toward addressing this challenge we have embarked upon global analysis of protein phosphorylation networks in either adipose tissue or skeletal muscle under different perturbation states including insulin stimulation, exercise or insulin resistance. This has unveiled the complex nature of these perturbations as well as a surprising heterogeneity in terms of the biological pathways that participate in metabolic homeostasis.
The details of some of these networks will be presented together with specific examples of some of the novel features that have merged from this kind of research.
